Honey is currently the focus of many research projects due to its varied biological activities including
antiinflammatory, antioxidant, antibacterial, antihypertensive and hypoglycemic effects. In the current study
antitumor effect of coriander honey was investigated in mature mice bearing Ehrlich ascites carcinoma (EAC) with
special reference to immune status. Coriander honey (500 mg/kg) caused decrease in tumor volume, packed cell
volume and viable cell count, and caused increase in non-viable cell count and mean survival time thereby
increasing life span of EAC bearing mice. The study of the effect of honey on immunological status in mice bearing
Ehrlich carcinoma showed that the levels of immunoglobulin M, G and A were increased following the administration
of coriander honey. It was also clear that coriander honey increased the phagocytic activity in mice bearing Ehrlich
carcinoma. There was reduction in the stimulation indices of lymphocyte transformation of mice bearing Ehrlich
carcinoma. Delayed hypersensitivity skin test revealed that the Ehrlich carcinoma reduced the reaction after 72
hours post inoculation with bovine serum albumin. The administration of honey caused the rise in skin thickness as
shown in Ehrlich carcinoma and subsequently treated with coriander honey with a rise of 0.61 mm as compared with
0.52 mm in EAC control group. The skin thickness in coriander honey group was the highest among all groups with
0.90 mm thickness. Based on these results, it can be concluded that coriander honey exhibited antitumor effect by
modulating cell mediated immune response and immunoglobulin levels, in EAC bearing mice.
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